Perspectives on The Development of Sidaguri-Rosella Powder Beverage Formula as An Antihypertensive Nutracetic
DOI:
https://doi.org/10.37287/picnhs.v7i1.2234Keywords:
antihypertensive, nutraceethical, rosella, sidaguri, qualitative studiesAbstract
Hypertension is a major health problem that contributes to an increased risk of cardiovascular disease. The development of local plant-based nutracetics is one of the potential complementary therapeutic alternatives to help control hypertension. This study aims to explore the perspective of pharmacists on the development of Sidaguri (Sida rhombifolia) and Rosella (Hibiscus sabdariffa) powder drink formulas as antihypertensive nutracetics. The research uses a qualitative approach with an exploratory study design. The research informants consisted of four pharmacists who were selected purposively based on their competence and experience in the fields of pharmacognosy, pharmaceuticals, pharmaceutical technology, and herbal product development. Data collection was conducted through in-depth interviews using semi-structured interview guidelines. The data was analyzed using thematic analysis. The results showed that all informants assessed that Sidaguri and Rosella had antihypertensive potential because they contained flavonoids, polyphenols, and anthocyanins that act as antioxidants and support the inhibition of angiotensin-converting enzyme (ACE). The informant also assessed that the form of powdered drink preparations has advantages in terms of practicality, stability, and public acceptance. In addition, the standardization of raw materials, evaluation of bioactive activity, product safety, and stability during storage are considered as important components in the development of antihypertensive nutracetics. This study concludes that the development of Sidaguri-Rosella powder beverage formula has the potential to be developed as an antihypertensive nutracetic that requires the support of further research related to bioactivity, safety, and clinical effectiveness.
References
Almajid, A., Bazroon, A., AlAhmed, A., & Bakhurji, O. (2023). Exploring the Health Benefits and Therapeutic Potential of Roselle (Hibiscus sabdariffa) in Human Studies: A Comprehensive Review. Cureus, 15(11), 1–10. https://doi.org/10.7759/cureus.49309
Costa-Font, J., & Sato, A. (2025). Cultural persistence and the “herbal medicine paradox”: Evidence from European data. Journal of Health Psychology, 30(2), 171–185. https://doi.org/10.1177/13591053241237031
Dehkhoda, B., Enayati, A., Mirzaei, H., Ghorbani, S., Soleimani, M. H., Amirkhanlou, S., & Sahebkar, A. (2024). Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial. Avicenna Journal of Phytomedicine, 14(4), 505–519. https://doi.org/10.22038/AJP.2024.23871
Hasyim, D. M., Anurogo, D., Bansaleng, Y. F., Hiola, S. F., & Anrip, N. (2025). Potential of Medicinal Plants in Indonesian Forest Biodiversity Conservation in Synergy with Pharmaceutical Technology for Modern Medicine. International Journal of Engineering, Science and Information Technology, 5(3), 200–207. https://doi.org/10.52088/ijesty.v5i3.899
Heidari, B., Avenatti, E., & Nasir, K. (2022). Pharmacotherapy for Essential Hypertension: A Brief Review. Methodist DeBakey Cardiovascular Journal, 18(5), 5–16. https://doi.org/10.14797/mdcvj.1175
Holdford, D. A. (2021). Perspectives on the pharmacist’s “product”: a narrative review. Pharmacy Practice, 19(2), 2430. https://doi.org/10.18549/PharmPract.2021.2.2430
Jiang, H., Zhang, N., Xie, L., Li, G., Chen, L., & Liao, Z. (2025). A Comprehensive Review of the Rehydration of Instant Powders: Mechanisms, Influencing Factors, and Improvement Strategies. Foods (Basel, Switzerland), 14(16), 1–15. https://doi.org/10.3390/foods14162883
Jiménez-Ferrer, E., Herrera-Ruiz, M., Campos-Vidal, Y., Flores-Franco, G., & Monterrosas-Brisson, N. (2025). Sida L.: Ethnobotany, Pharmacology, and Phytochemistry: A Review. Plants, 14(19), 1–46. https://doi.org/10.3390/plants14193115
Masenga, S. K., & Kirabo, A. (2023). Hypertensive heart disease: risk factors, complications and mechanisms. Frontiers in Cardiovascular Medicine, 10(1), 1–12. https://doi.org/10.3389/fcvm.2023.1205475
Mubeen, B., Hasnain, A., Naqvi, S. A. H., Hakim, F., Naqvi, S. S. H., Hassan, M. Z., Iqbal, M. U., Moustafa, M., Alshaharni, M. O., & Duan, M. (2025). Phytochemicals as Multi-Target Therapeutic Agents for Oxidative Stress-Driven Pathologies: Mechanisms, Synergies, and Clinical Prospects. Phyton-International Journal of Experimental Botany, 94(7), 1941–1971. https://doi.org/https://doi.org/10.32604/phyton.2025.064056
Muharram, F. R., Widyahening, I. S., & Danaei, G. (2025). Hypertension care performance in Indonesia: evidence from three waves of nationally representative cross-sectional surveys. BMJ Open, 15(12), e109588. https://doi.org/10.1136/bmjopen-2025-109588
Muyumba, N. W., Mutombo, S. C., Sheridan, H., Nachtergael, A., & Duez, P. (2021). Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications. Talanta Open, 4(2), 100070. https://doi.org/10.1016/j.talo.2021.100070
Niu, Y., Chen, X., Xiao, L., Li, W., Feng, L., & Aierken, A. (2025). The relationship between dietary flavonoid intake and hypertension: a cross-sectional study from NHANES. Frontiers in Cardiovascular Medicine, 12(2), 1–11. https://doi.org/10.3389/fcvm.2025.1518549
Olalekan, S. O., Okwute, P. G., Osonuga, I. O., Adegbesan, B. O., Ezima, E. N., & Adeyemi, I. M. (2025). Clinical relevance of nutraceuticals in hypertension management: mechanisms, efficacy, and integration into therapeutic protocols. Bulletin of the National Research Centre, 49(1), 1–12. https://doi.org/10.1186/s42269-025-01329-z
Olędzki, R. (2025). Polyphenolic Compounds in the Prevention and Treatment of Hypertension: A Review. International Journal of Molecular Sciences, 26(21), 1–11. https://doi.org/10.3390/ijms262110665
Puri, V., Nagpal, M., Singh, I., Singh, M., Dhingra, G. A., Huanbutta, K., Dheer, D., Sharma, A., & Sangnim, T. (2022). A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges. Nutrients, 14(21), 1–10. https://doi.org/10.3390/nu14214637
Ramachandran, R. P., Nadimi, M., Cenkowski, S., & Paliwal, J. (2024). Advancement and Innovations in Drying of Biopharmaceuticals, Nutraceuticals, and Functional Foods. Food Engineering Reviews, 16(4), 540–566. https://doi.org/10.1007/s12393-024-09381-7
Setiani, L. A., Saputri, F. C., Yanuar, A., & Mun’im, A. (2024). Determining antihypertensive herbal formulas based on molecular mechanisms and protein-compound interactions of selected Indonesian medicinal plants using a network pharmacological approach. Journal of Applied Pharmaceutical Science, 14(3), 252–262. https://doi.org/10.7324/JAPS.2024.152201
Sucipto, A., Harmili, H., & Fadlilah, S. (2021). Effectiveness of Hibiscus Sabdariffa on Blood Pressure of Hypertenasion Patients. Jurnal Keperawatan Respati Yogyakarta, 8(2), 99–102.
Wang, H., Chen, Y., Wang, L., Liu, Q., Yang, S., & Wang, C. (2023). Advancing herbal medicine: enhancing product quality and safety through robust quality control practices. Frontiers in Pharmacology, 14(2), 1265178. https://doi.org/10.3389/fphar.2023.1265178
Zahra, M., Abrahamse, H., & George, B. P. (2024). Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine. Antioxidants, 13(8), 1–26. https://doi.org/10.3390/antiox13080922
Zhang, C., Zhong, X., Bao, S., Urtnasan, M., & Li, M. (2025). Main factors affecting the efficacy of medicinal plants during the cultivation process. Frontiers in Plant Science, 16(1), 1634926. https://doi.org/10.3389/fpls.2025.1634926