The Impact of Lead Levels in Blood on Blood Pressure, Body Mass Index, and Hand Strength in Rice Farmers”
DOI:
https://doi.org/10.37287/ijghr.v8i1.1671Keywords:
blood pressure, body mass index, hand strength, lead in blood, rice farmersAbstract
Lead contamination in pesticides poses a serious threat to health due to its bioaccumulative and toxic properties to various organ systems, including the nervous, hormonal, and cardiovascular systems. This study aims to determine the relationship between blood lead levels and blood pressure, body mass index (BMI), and handgrip strength in rice farmers in Tlingsing Village, Cawas District, Klaten Regency. This analytical study used a cross-sectional design with a sample of 24 rice farmers. Venous blood samples were taken using 3 cc EDTA vacuum tubes and examined for lead levels using the Graphite Furnace Atomic Absorption Spectrophotometry (GFAAS) method at BBLK Yogyakarta. Blood pressure was measured using an Omron 7120 digital sphygmomanometer, BMI using a HN 289 digital scale and a GEA SH2A stature meter, and hand strength using a Camry EH101 electronic hand dynamometer. Data analysis was carried out using a bivariate correlation test at a 95% confidence level (p=0.05). The results showed that blood lead levels were significantly associated with blood pressure (p=0.028), with a percentage of stage 1 hypertension of 50.0% and hypertensive crisis of 45.8%. Lead levels were not significantly associated with BMI (p=0.082), with 29.2% of participants classified as overweight and 8.3% as obese. There was no significant association with hand grip strength (p=0.360), with 20.8% of participants classified as having medium strength and 33.3% as having low strength.
References
Anne C. Looker, Ph. D. ; and C.-Y. W. Ph. D. (2015, January). Prevalence of Reduced Muscle Strength in Older U.S. Adults: United States, 2011–2012. Centers for Disease Control : National Center for Health Statistics. https://www.cdc.gov/nchs/data/databriefs/db179.pdf
Bjørklund, G., Dadar, M., Chirumbolo, S., Aaseth, J., & Peana, M. (2020). Metals, autoimmunity, and neuroendocrinology: Is there a connection? Environmental Research, 187, 109541.
CDC. (2024, April). Blood Lead Level Guidance. Centers for Disease Control. https://www.cdc.gov/niosh/lead/bll-reference/index.html
Clarà, PC, Jerez, FR, Ramírez, JB, & González, CM (2023). Deposition and clinical impact of inhaled particles in the lung. Archives of Bronconeumologia , 59 (6), 377–382.
Fajriani, GN (2019). Relationship between pesticide spraying intensity and cholinesterase levels in farmers' blood in Pasirhalang Village, West Bandung Regency. Meditory: The Journal of Medical Laboratory , 7 (2).
Fan, Y., Jiang, X., Xiao, Y., Li, H., Chen, J., & Bai, W. (2024). Natural antioxidants mitigate heavy metal induced reproductive toxicity: Prospective mechanisms and biomarkers. Critical Reviews in Food Science and Nutrition , 64 (31), 11530–11542.
Febriana, S. A., Khalidah, M., Huda, F. N., Sutarni, S., Mahayana, I., Indrastuti, N., Setyopranoto, I., Waskito, F., Prawiroranu, S., & Dwianingsih, E. K. (2023). Prevalence of pesticide related occupational diseases among Indonesian vegetable farmers–A collaborative work. Toxicology Reports, 10, 571–579.
Flora, G., Gupta, D., & Tiwari, A. (2012a). Toxicity of lead: a review with recent updates. Interdisciplinary Toxicology, 5(2), 47.
Flora, G., Gupta, D., & Tiwari, A. (2012b). Toxicity of lead: a review with recent updates. Interdisciplinary Toxicology, 5(2), 47.
Gbemavo, C., & Bouchard, M. (2019). Hand Grip Strength in Relation to Blood Levels of Lead, Mercury, Cadmium, Selenium, and Manganese Among Adults Living in the United States. Environmental Epidemiology, 3, 38.
Gómez-Redondo, P., Marín, V., Leal-Martín, J., Ruiz-Moreno, C., Giráldez-Costas, V., Urdiola, P., Ara, I., & Mañas, A. (2022). Association between Physical Activity Guidelines and Sedentary Time with Workers’ Health-Related Quality of Life in a Spanish Multinational Company. International Journal of Environmental Research and Public Health, 19(11), 6592.
Guazzi, M., Borlaug, B., Metra, M., Losito, M., Bandera, F., Alfonzetti, E., Boveri, S., & Sugimoto, T. (2021). Revisiting and implementing the weber and ventilatory functional classifications in heart failure by cardiopulmonary imaging phenotyping. Journal of the American Heart Association, 10(5), e018822.
Hara, A., Thijs, L., Asayama, K., Gu, Y.-M., Jacobs, L., Zhang, Z.-Y., Liu, Y.-P., Nawrot, T. S., & Staessen, J. A. (2015). Blood pressure in relation to environmental lead exposure in the national health and nutrition examination survey 2003 to 2010. Hypertension, 65(1), 62–69.
Harini, S., Susilowati, I. T., Dewi, N., Harningsih, T., Widhiyastuti, E., Purwati, P., Saroh, D., Mulyanto, A. D., & Saefi, M. (2025). Canonical Correlation Analysis of Lead Concentration in Hair Impacted With IQ, Antisocial Behavior, and Hand Strength at High School Students Community. Journal of Multidisciplinary Applied Natural Science, 5(1), 175–183.
Konthonbut, P., Kongtip, P., Nankongnab, N., Tipayamongkholgul, M., Yoosook, W., & Woskie, S. (2020). Paraquat exposure of backpack sprayers in agricultural area in Thailand. Human and Ecological Risk Assessment: An International Journal, 26(10), 2798–2811.
Lanphear, B. P., Rauch, S., Auinger, P., Allen, R. W., & Hornung, R. W. (2018a). Low-level lead exposure and mortality in US adults: a population-based cohort study. The Lancet Public Health, 3(4), e177–e184. https://doi.org/10.1016/S2468-2667(18)30025-2
Lanphear, B. P., Rauch, S., Auinger, P., Allen, R. W., & Hornung, R. W. (2018b). Low-level lead exposure and mortality in US adults: a population-based cohort study. The Lancet Public Health, 3(4), e177–e184.
Lanphear, B. P., Rauch, S., Auinger, P., Allen, R. W., & Hornung, R. W. (2018c). Low-level lead exposure and mortality in US adults: a population-based cohort study. The Lancet Public Health, 3(4), e177–e184.
Lari, S., Vanka, J., Jee, B., Pandiyan, A., Yamagani, P., Kumar, S. B., Naidu, M., & Jonnalagadda, P. (2023). Mitigation of pesticide residue levels in the exposed dermal regions of occupationally exposed farmworkers by use of personal protective equipment. Frontiers in Public Health, 11, 1232149.
Li, H., & Sansalone, J. (2020). Multi-scale physical model simulation of particle filtration using computational fluid dynamics. Journal of Environmental Management, 271, 111021. https://doi.org/https://doi.org/10.1016/j.jenvman.2020.111021
Lin, L.-Z., Zeng, L.-W. (2022). Outdoor light at night, overweight, and obesity in school-aged children and adolescents. Environmental Pollution , 305 , 119306. https://doi.org/https://doi.org/10.1016/j.envpol.2022.119306
Minayo, M. C. de S., Pinto, L. W., Assis, S. G. de, Cavalcante, F. G., & Mangas, R. M. do N. (2012). Mortality trend by suicide in the Brazilian population and population, 1980-2006. Revista de Saúde Pública , 46 , 300–309.
Navas-Acien, A., Guallar, E., Silbergeld, E. K., & Rothenberg, S. J. (2007). Lead exposure and cardiovascular disease—a systematic review. Environmental Health Perspectives, 115(3), 472–482.
Ndayambaje, B., Amuguni, H., Coffin-Schmitt, J., Sibo, N., Ntawubizi, M., & VanWormer, E. (2019). Pesticide application practices and knowledge among small-scale local rice growers and communities in Rwanda: a cross-sectional study. International Journal of Environmental Research and Public Health, 16(23), 4770.
Oberdörster, G., & Elder, A. (2007). Metal particles and extrapulmonary transport: oberdörster and elder respond. Environmental Health Perspectives, 115(2), A70–A71.
Okoroiwu, H.U., & Iwara, I.A. (2018). Dichlorvos toxicity: A public health perspective. Interdisciplinary Toxicology , 11 (2), 129–137.
Pradana Sulistiyono Putra, I., Setiani, O., & Hanani Darundiati, Y. (2025). Factors Associated with the Incidence of Hypertension and Mild Cognitive Impairment in Farmers in Bandungan District, Semarang Regency. PREPOTIFY : Journal of Public Health , 9 (2), 4005–4021. https://doi.org/DOI:https://doi.org/10.31004/prepotif.v9i2.47120
Putrawan, IBP, & Kuswardhani, RAT (2011). Factors determining handgrip strength in elderly patients at the Tangtu Nursing Home and the Geriatric Polyclinic of Sanglah General Hospital, Denpasar. Journal of Internal Medicine , 12 (2), 87–91.
Qu, W., Du, G.-L., Feng, B., & Shao, H. (2019). Effects of oxidative stress on blood pressure and electrocardiogram findings in workers with occupational exposure to lead. Journal of International Medical Research , 47 (6), 2461–2470.
Rachael Zimlich, B.R. (2023, December). Readings for Stages 1–3 of Hypertension . Verywellhealth. https://www.verywellhealth.com/stages-of-hypertension-8347547
Rehman, K., Fatima, F., Waheed, I., & Akash, M. S. H. (2018). Prevalence of exposure of heavy metals and their impact on health consequences. Journal of Cellular Biochemistry, 119(1), 157–184.
Reymond, N., Glanzmann, V., Huisman, S., Plagellat, C., Weyermann, C., & Estoppey, N. (2023). An improved Chemcatcher-based method for the integrative passive sampling of 44 hydrophilic micropollutants in surface water – Part B: Field implementation and comparison with automated active sampling. Science of The Total Environment, 871, 161937. https://doi.org/https://doi.org/10.1016/j.scitotenv.2023.161937
Rudzi, S. K., Ho, Y. Bin, Tan, E. S. S., Jalaludin, J., & Ismail, P. (2022). Exposure to airborne pesticides and its residue in blood serum of paddy farmers in Malaysia. International Journal of Environmental Research and Public Health, 19(11), 6806.
Samuel D. Emmerich, D. V. M. , C. D. F. M. S. P. H. , B. S. M. D. , M. P. H. , and C. L. O. Ph. D. , M. R. P. (2024, September). Obesity and Severe Obesity Prevalence in Adults: United States, August 2021–August 2023. Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/products/databriefs/db508.htm
Sarkar, S., & Schmued, L. (2012). In vivo administration of fluorescent dextrans for the specific and sensitive localization of brain vascular pericytes and their characterization in normal and neurotoxin exposed brains. NeuroToxicology, 33(3), 436–443. https://doi.org/https://doi.org/10.1016/j.neuro.2012.04.004
Scinicariello, F., Abadin, H. G., & Murray, H. E. (2011). Association of low-level blood lead and blood pressure in NHANES 1999–2006. Environmental Research, 111(8), 1249–1257.
Sharma, N., & Singhvi, R. (2017). Effects of chemical fertilizers and pesticides on human health and environment: a review. International Journal of Agriculture, Environment and Biotechnology, 10(6), 675–680.
Singh, A., Sharma, R. K., Agrawal, M., & Marshall, F. M. (2010). Health risk assessment of heavy metals via dietary intake of foodstuffs from the wastewater irrigated site of a dry tropical area of India. Food and Chemical Toxicology, 48(2), 611–619.
Tawakkalni, I., & Winarko, N. H. (2019). FAKTOR YANG MEMPENGARUHI KADAR KOLINESTERASE DALAM DARAH PADA BURUH TANI.
Walker-Bone, K., D’Angelo, S., Syddall, H. E., Palmer, K. T., Cooper, C., Coggon, D., & Sayer, A. A. (2016). Heavy manual work throughout the working lifetime and muscle strength among men at retirement age. Occupational and Environmental Medicine, 73(4), 284–286.
Wang, N., Chen, C., Nie, X., Han, B., Li, Q., Chen, Y., Zhu, C., Chen, Y., Xia, F., & Cang, Z. (2015). Blood lead level and its association with body mass index and obesity in China-Results from SPECT-China study. Scientific Reports, 5(1), 18299.
Wang, X., Mukherjee, B., & Park, S. K. (2018). Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among US adults in NHANES 2003–2014. Environment International, 121, 683–694.
Wattigney, W. A., Irvin-Barnwell, E., Li, Z., & Ragin-Wilson, A. (2019). Biomonitoring of mercury and persistent organic pollutants in Michigan urban anglers and association with fish consumption. International Journal of Hygiene and Environmental Health, 222(6), 936–944.
Wijayanti, A. W., Suhartono, S., & Joko, T. (2019). Studi Prevalensi Kejadian Hipertensi pada Petani di Dusun Candi, Kecamatan Bandungan, Kabupaten Semarang.
Wu, W. L., Yang, Y., Tan, B. K., Lin, S. L., Chen, Y. P., & Hu, J. M. (2023). Endocrine disruptors in foods: Overlooked factors contributing to the prevalence of obesity. Czech Journal of Food Sciences, 41(6), 393–405.
Yan, L. D., Rouzier, V., Pierre, J. L., Lee, M. H., Muntner, P., Parsons, P. J., Apollon, A., St-Preux, S., Malebranche, R., & Pierre, G. (2022). High lead exposure associated with higher blood pressure in Haiti: a warning sign for low-income countries. Hypertension, 79(1), 283–290.
You, G., Wang, P., Hou, J., Wang, C., Miao, L., Xu, Y., & Feng, T. (2018). Influence of CeO2 nanoparticles on viscoelastic properties of sludge: role of extracellular polymeric substances. Environmental Research, 167, 34–41.
Yu, Y.-L., Yang, W.-Y., Hara, A., Asayama, K., Roels, H. A., Nawrot, T. S., & Staessen, J. A. (2023). Public and occupational health risks related to lead exposure updated according to present-day blood lead levels. Hypertension Research, 46(2), 395–407.
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