The Effectiveness of Probiotic Administration as A Novel Therapeutic Target for Hypertension During Pregnancy Induced by Primary and Secondary Factors: A Systematic Literature Review of Preclinical Studies
DOI:
https://doi.org/10.37287/ijghr.v7i6.307Abstract
Hypertension during pregnancy, including preeclampsia, remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide. The complex pathogenesis of pregnancy-related hypertension involves endothelial dysfunction, impaired angiogenesis, oxidative stress, and immune dysregulation. Conventional pharmacological therapies continue to face limitations in terms of efficacy and safety for pregnant women. Therefore, there is an urgent need for safer and more effective molecular-based therapeutic alternatives, one of which is the use of probiotics. The aim of this systematic review is to analyse the potential effectiveness of probiotic administration as a novel therapeutic target for pregnancy-induced hypertension driven by primary and secondary factors. This systematic review was conducted following the PRISMA guidelines. A comprehensive literature search was performed across databases including Google Scholar, PubMed, Taylor & Francis, and ScienceDirect, covering publications from 2015 to 2025. Inclusion criteria were applied based on the PICOS framework. A total of 14 preclinical in vivo studies met the inclusion criteria. Probiotics such as Akkermansia muciniphila, Bifidobacterium bifidum, Lactobacillus spp., Limosilactobacillus spp., and Lactiplantibacillus plantarum demonstrated significant effectiveness in reducing systolic and diastolic blood pressure, improving endothelial function, suppressing inflammation, and mitigating oxidative stress. These effects were mediated through mechanisms involving gut microbiota modulation and regulation of the renin-angiotensin system. Probiotics hold promise as a safe and effective alternative therapy for reducing hypertension during pregnancy and may support the development of future non-pharmacological, microbiota-based therapeutic strategies.
References
Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G, Januszewicz A, et al. (2023). ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension. J Hypertens [Internet] 2023;41(12):1874–2071. Available from: https://journals.lww.com/10.1097/HJH.0000000000003480.
Mills KT, Stefanescu A, He J. (2020). The global epidemiology of hypertension. Nat Rev Nephrol [Internet] 2020;16(4):223–37. Available from: https://www.nature.com/articles/s41581-019-0244-2.
Zhou B, Carrillo-Larco RM, Danaei G, Riley LM, Paciorek CJ, Stevens GA, et al. (2021). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet [Internet] 2021;398(10304):957–80. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0140673621013301.
Masenga SK, Kirabo A. (2023). Hypertensive heart disease: risk factors, complications and mechanisms. Front Cardiovasc Med [Internet] 2023;10. Available from: https://www.frontiersin.org/articles/10.3389/fcvm.2023.1205475/full.
Garovic VD, Dechend R, Easterling T, Karumanchi SA, McMurtry Baird S, Magee LA, et al. (2022). Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association. Hypertension [Internet] 2022;79(2). Available from: https://www.ahajournals.org/doi/10.1161/HYP.0000000000000208.
Braunthal S, Brateanu A. (2019). Hypertension in pregnancy: Pathophysiology and treatment. SAGE Open Med [Internet] 2019;7. Available from: https://journals.sagepub.com/doi/10.1177/2050312119843700.
Rocha de Moura MD, Margotto PR, Nascimento Costa K, Carvalho Garbi Novaes MR. (2021). Hypertension induced by pregnancy and neonatal outcome: Results from a retrospective cohort study in preterm under 34 weeks. PLoS One [Internet] 2021;16(8):e0255783. Available from: https://dx.plos.org/10.1371/journal.pone.0255783.
Karrar SA, Martingano DJ, Hong PL. Preeclampsia [Internet]. (2025). Available from: http://www.ncbi.nlm.nih.gov/pubmed/35177220.
Magee LA, Brown MA, Hall DR, Gupte S, Hennessy A, Karumanchi SA, et al. (2022). The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens [Internet] 2022;27:148–69. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2210778921005237.
di Pasquo E, Giannubilo SR, Valentini B, Salvi S, Rullo R, Fruci S, et al. (2024). The “Preeclampsia and Hypertension Target Treatment” study: a multicenter prospective study to evaluate the effectiveness of the antihypertensive therapy based on maternal hemodynamic findings. Am J Obstet Gynecol MFM [Internet] 2024;6(5):101368. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2589933324000946.
Aziz F, Khan MF, Moiz A. (2024). Gestational diabetes mellitus, hypertension, and dyslipidemia as the risk factors of preeclampsia. Sci Rep [Internet] 2024;14(1):6182. Available from: https://www.nature.com/articles/s41598-024-56790-z.
Simard JF, Rossides M, Arkema E V., Svenungsson E, Wikström A, Mittleman MA, et al. (2021). Maternal Hypertensive Disorders in Pregnant Women With Systemic Lupus Erythematosus and Future Cardiovascular Outcomes. Arthritis Care Res (Hoboken) [Internet] 2021;73(4):574–9. Available from: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr.24160.
Ernawati E, Aditiawarman A, Sulistyono A, Hasanah K, Ridfah SN, Akbar MIA, et al. (2023). The Risk of Persistent Hypertension and Chronic Kidney Disease in Early- and Late-Onset Preeclampsia: A Report From Developing Country. Cureus [Internet] 2023;Available from: https://www.cureus.com/articles/212675-the-risk-of-persistent-hypertension-and-chronic-kidney-disease-in-early--and-late-onset-preeclampsia-a-report-from-developing-country.
Steinthorsdottir V, McGinnis R, Williams NO, Stefansdottir L, Thorleifsson G, Shooter S, et al. (2020). Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nat Commun [Internet] 2020;11(1):5976. Available from: https://www.nature.com/articles/s41467-020-19733-6.
Zarezadeh M, Musazadeh V, Ghalichi F, Kavyani Z, Nasernia R, Parang M, et al. (2023). Effects of probiotics supplementation on blood pressure: An umbrella meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis [Internet] 2023;33(2):275–86. Available from: https://linkinghub.elsevier.com/retrieve/pii/S093947532200374X.
Chen Z, Liang W, Liang J, Dou J, Guo F, Zhang D, et al. (2023). Probiotics: functional food ingredients with the potential to reduce hypertension. Front Cell Infect Microbiol [Internet] 2023;13. Available from: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1220877/full.
Romero M, Duarte J. (2023). Probiotics and Prebiotics in Cardiovascular Diseases. Nutrients [Internet] 2023;15(17):3686. Available from: https://www.mdpi.com/2072-6643/15/17/3686.
Mahmoudi S, Ghane MR, Goodarzi H, Faraji M, Shahjooie F, Javadzadeh HR. (2021). The Effect of Probiotic Supplements on Oxidative Stress in Various Diseases: A Systematic Review. J Appl Biotechnol Reports 2021;8(4):326–31.
Yang F, Chen H, Gao Y, An N, Li X, Pan X, et al. (2020). Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment. Biomed Pharmacother [Internet] 2020;130:110503. Available from: https://linkinghub.elsevier.com/retrieve/pii/S075333222030696X.
Mahdavi-Roshan M, Salari A, Kheirkhah J, Ghorbani Z. (2022). The Effects of Probiotics on Inflammation, Endothelial Dysfunction, and Atherosclerosis Progression: A Mechanistic Overview. Hear Lung Circ [Internet] 2022;31(5):e45–71. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1443950621012427.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev [Internet] 2021;10(1):89. Available from: https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-021-01626-4.
Methley AM, Campbell S, Chew-Graham C, McNally R, Cheraghi-Sohi S. (2014). PICO, PICOS and SPIDER: a comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Serv Res [Internet] 2014;14(1):579. Available from: https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-014-0579-0.
Amir-Behghadami M, Janati A. (2020). Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews. Emerg Med J [Internet] 2020;37(6):387–387. Available from: https://emj.bmj.com/lookup/doi/10.1136/emermed-2020-209567.
Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. (2020). Preeclampsia—Pathophysiology and Clinical Presentations. J Am Coll Cardiol [Internet] 2020;76(14):1690–702. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0735109720362987.
Staff AC, Fjeldstad HE, Fosheim IK, Moe K, Turowski G, Johnsen GM, et al. (2022). Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia. Am J Obstet Gynecol [Internet] 2022;226(2):S895–906. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0002937820311169.
Lyall F, Robson SC, Bulmer JN. (2013). Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction. Hypertension [Internet] 2013;62(6):1046–54. Available from: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.113.01892.
Cao C, Saxena R, Gray KJ. (2024). Placental Origins of Preeclampsia: Insights from Multi-Omic Studies. Int J Mol Sci [Internet] 2024;25(17):9343. Available from: https://www.mdpi.com/1422-0067/25/17/9343.
Hesson AM, Langen ES, Plazyo O, Gudjonsson JE, Ganesh SK. (2023). Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension. BMC Med Genomics [Internet] 2023;16(1):91. Available from: https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-023-01522-x.
Cerdeira AS, Vatish M, Lecarpentier E. (2020). One Step Closer to a Cure for Preeclampsia? Hypertension [Internet] 2020;76(4):1081–3. Available from: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.15112.
Torres-Vergara P, Rivera R, Escudero C. (2022). How Soluble Fms-Like Tyrosine Kinase 1 Could Contribute to Blood-Brain Barrier Dysfunction in Preeclampsia? Front Physiol [Internet] 2022;12. Available from: https://www.frontiersin.org/articles/10.3389/fphys.2021.805082/full.
Titus A, Marappa-Ganeshan R. Physiology Endothelin [Internet]. (2023). Available from: http://www.ncbi.nlm.nih.gov/pubmed/29947530.
Li MW, Mian MOR, Barhoumi T, Rehman A, Mann K, Paradis P, et al. (2013). Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein e knockout mice. Arterioscler Thromb Vasc Biol 2013;33(10):2306–15.
Ssengonzi R, Wang Y, Maeda-Smithies N, Li F. (2024). Endothelial Nitric Oxide synthase (eNOS) in Preeclampsia: An Update. J Pregnancy Child Heal [Internet] 2024;6(1). Available from: https://www.gavinpublishers.com/article/view/endothelial-nitric-oxide-synthase-enos-in-preeclampsia-an-update.
Kaihara JNS, Minami CK, Peraçoli MTS, Romão-Veiga M, Ribeiro-Vasques VR, Peraçoli JC, et al. (2023). Plasma eNOS Concentration in Healthy Pregnancy and in Hypertensive Disorders of Pregnancy: Evidence of Reduced Concentrations in Pre-Eclampsia from Two Independent Studies. Diseases [Internet] 2023;11(4):155. Available from: https://www.mdpi.com/2079-9721/11/4/155.
Saleh L, Verdonk K, Visser W, van den Meiracker AH, Danser AHJ. (2016). The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia. Ther Adv Cardiovasc Dis [Internet] 2016;10(5):282–93. Available from: https://journals.sagepub.com/doi/10.1177/1753944715624853.
Tsikouras P, Nikolettos K, Kotanidou S, Kritsotaki N, Oikonomou E, Bothou A, et al. (2025). Renal Function and the Role of the Renin–Angiotensin–Aldosterone System (RAAS) in Normal Pregnancy and Pre-Eclampsia. J Clin Med [Internet] 2025;14(3):892. Available from: https://www.mdpi.com/2077-0383/14/3/892.
LaMarca B, Cornelius D, Wallace K. (2013). Elucidating Immune Mechanisms Causing Hypertension During Pregnancy. Physiology [Internet] 2013;28(4):225–33. Available from: https://www.physiology.org/doi/10.1152/physiol.00006.2013.
Salazar Garcia MD, Mobley Y, Henson J, Davies M, Skariah A, Dambaeva S, et al. Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia. J Reprod Immunol [Internet] 2018;125:25–31. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0165037817302000.
Zhou Q, Wu Y, Zhang D. (2023). Exploring the role of T helper subgroups and their cytokines in the development of pregnancy-induced hypertension. Front Immunol [Internet] 2023;14. Available from: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1126784/full.
Aouache R, Biquard L, Vaiman D, Miralles F. (2018). Oxidative Stress in Preeclampsia and Placental Diseases. Int J Mol Sci [Internet] 2018;19(5):1496. Available from: https://www.mdpi.com/1422-0067/19/5/1496.
Phoswa WN, Khaliq OP. (2021). The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus). Oxid Med Cell Longev [Internet] 2021;2021(1). Available from: https://onlinelibrary.wiley.com/doi/10.1155/2021/5581570.
Deer E, Vaka VR, McMaster KM, Wallace K, Cornelius DC, Amaral LM, et al. (2021). Vascular endothelial mitochondrial oxidative stress in response to preeclampsia: a role for angiotension II type 1 autoantibodies. Am J Obstet Gynecol MFM [Internet] 2021;3(1):100275. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2589933320302688.
Bodke H, Jogdand S. (2022). Role of Probiotics in Human Health. Cureus [Internet] 2022;Available from: https://www.cureus.com/articles/111413-role-of-probiotics-in-human-health.
Pavlidou E, Fasoulas A, Mantzorou M, Giaginis C. (2022). Clinical Evidence on the Potential Beneficial Effects of Probiotics and Prebiotics in Cardiovascular Disease. Int J Mol Sci [Internet] 2022;23(24):15898. Available from: https://www.mdpi.com/1422-0067/23/24/15898.
McDougall A, Nguyen R, Nguyen PY, Allen C, Cheang S, Makama M, et al. (2024). The effects of probiotics administration during pregnancy on preeclampsia and associated maternal, fetal, and newborn outcomes: a systematic review and meta-analysis. Am J Obstet Gynecol MFM [Internet] 2024;6(4):101322. Available from: https://linkinghub.elsevier.com/retrieve/pii/S258993332400048X.
Liu W, Zhang T, Wang J, Zhao G, Hou Y. (2023). Protective Effect of Akkermansia muciniphila on the Preeclampsia-Like Mouse Model. Reprod Sci [Internet] 2023;30(9):2623–33. Available from: https://doi.org/10.1007/s43032-023-01206-y.
Peng L, Yin Q, Wang X, Zhong Y, Wang Y, Cai W, et al. (2024). Pasteurized Akkermansia muciniphila Ameliorates Preeclampsia in Mice by Enhancing Gut Barrier Integrity, Improving Endothelial Function, and Modulating Gut Metabolic Dysregulation. Microorganisms 2024;12(12).
Chen Y, Ou Z, Pang M, Tao Z, Zheng X, Huang Z, et al. (2023). Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model. J Extracell Vesicles 2023;12(5).
He P, He H, Su C, Liu Y, Wang J, Wu Y, et al. (2025). Amomum villosum Lour. alleviates pre-eclampsia by inducing enrichment of Bifidobacterium bifidum through vanillic acid to inhibit placental ferroptosis. J Ethnopharmacol [Internet] 2025;340(December 2024):119217. Available from: https://doi.org/10.1016/j.jep.2024.119217.
Sun BM, Meng L, Liu H, Bao D. (2020). Changes in intestinal flora in preeclampsia rats and effects of probiotics on their inflammation and blood pressure. Eur Rev Med Pharmacol Sci 2020;24(19):10155–61.
Yi L, Min JT, Jun CL, Long HX, Khoo HE, Ying ZJ, et al. (2024). Buffalo yogurt fermented with commercial starter and Lactobacillus plantarum originating from breast milk lowered blood pressure in pregnant hypertensive rats. J Dairy Sci [Internet] 2024;107(1):62–73. Available from: http://dx.doi.org/10.3168/jds.2023-23566.
Hsu CN, Lin YJ, Hou CY, Tain YL. (2018). Maternal administration of probiotic or prebiotic prevents male adult rat offspring against developmental programming of hypertension induced by high fructose consumption in pregnancy and lactation. Nutrients2018;10(9).
Hsu CN, Hou CY, Chan JYH, Lee C Te, Tain YL. (2019). Hypertension programmed by perinatal high-fat diet: Effect of maternal gut microbiota-targeted therapy. Nutrients 2019;11(12).
Chao YM, Tain YL, Lee WC, Wu KLH, Yu HR, Chan JYH. (2022). Protection by -Biotics against Hypertension Programmed by Maternal High Fructose Diet: Rectification of Dysregulated Expression of Short-Chain Fatty Acid Receptors in the Hypothalamic Paraventricular Nucleus of Adult Offspring. Nutrients2022;14(20).
De Oliveira Y, Cavalcante RGS, Cavalcanti Neto MP, Magnani M, Braga VDA, De Souza EL, et al. (2020). Oral administration of Lactobacillus fermentum post-weaning improves the lipid profile and autonomic dysfunction in rat offspring exposed to maternal dyslipidemia. Food Funct 2020;11(6):5581–94.
Toral M, Robles-Vera I, Romero M, de la Visitación N, Sánchez M, O’Valle F, et al. (2019). Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus. FASEB J 2019;33(9):10005–18.
Li B, Shi Y, Qiu W, Lin Q, Zeng S, Hou Y, et al. (2023). Limosilactobacillus reuteri ameliorates preeclampsia in mice via improving gut dysbiosis and endothelial dysfunction. Biomed Pharmacother [Internet] 2023;161(December 2022):114429. Available from: https://doi.org/10.1016/j.biopha.2023.114429.
Do Nascimento LCP, De Souza EL, De Luna Freire MO, De Andrade Braga V, De Albuqeurque TMR, Lagranha CJ, et al. (2022). Limosilactobacillus fermentum prevents gut-kidney oxidative damage and the rise in blood pressure in male rat offspring exposed to a maternal high-fat diet. J Dev Orig Health Dis 2022;13(6):719–26.
Guimarães KS de L, Braga V de A, Noronha SISR de, Costa WKA da, Makki K, Cruz J de C, et al. (2020). Lactiplantibacillus plantarum WJL administration during pregnancy and lactation improves lipid profile, insulin sensitivity and gut microbiota diversity in dyslipidemic dams and protects male offspring against cardiovascular dysfunction in later life. Food Funct [Internet] 2020;11(10):8939–50. Available from: https://xlink.rsc.org/?DOI=D0FO01718C.
Iwaza R, Wasfy RM, Dubourg G, Raoult D, Lagier JC. (2022). Akkermansia muciniphila: The state of the art, 18 years after its first discovery. Front Gastroenterol 2022;1(October):1–19.
Panzetta ME, Valdivia RH. (2024). Akkermansia in the gastrointestinal tract as a modifier of human health. Gut Microbes [Internet] 2024;16(1). Available from: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2406379.
Xu Y, Duan J, Wang D, Liu J, Chen X, Qin XY, et al. (2023). Akkermansia muciniphila Alleviates Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Mice. Metabolites [Internet] 2023;13(2):194. Available from: https://www.mdpi.com/2218-1989/13/2/194.
Peña-Cearra A, Palacios A, Pellon A, Castelo J, Pasco ST, Seoane I, et al. (2024). Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation. Commun Biol [Internet] 2024;7(1):192. Available from: https://www.nature.com/articles/s42003-024-05867-6.
Liu E, Ji X, Zhou K. (2024). Akkermansia muciniphila for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies. Nutrients [Internet] 2024;16(20):3440. Available from: https://www.mdpi.com/2072-6643/16/20/3440.
Druart C, Plovier H, Van Hul M, Brient A, Phipps KR, de Vos WM, et al. (2021). Toxicological safety evaluation of pasteurized Akkermansia muciniphila. J Appl Toxicol [Internet] 2021;41(2):276–90. Available from: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.4044.
Liu H, Zhang Q, Wang S, Weng W, Jing Y, Su J. (2022). Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives. Bioact Mater [Internet] 2022;14:169–81. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2452199X21005612.
Qian D, Xu P, Wang X, Du C, Zhao X, Xu J. (2025). Bacterial extracellular vesicles for gut microbiome-host communication and drug development. Acta Pharm Sin B [Internet] 2025;Available from: https://linkinghub.elsevier.com/retrieve/pii/S2211383525001261.
Sadeghpour Heravi F, Hu H. (2023). Bifidobacterium: Host–Microbiome Interaction and Mechanism of Action in Preventing Common Gut-Microbiota-Associated Complications in Preterm Infants: A Narrative Review. Nutrients [Internet] 2023;15(3):709. Available from: https://www.mdpi.com/2072-6643/15/3/709.
Ma X, Mo J, Shi L, Cheng Y, Feng J, Qin J, et al. (2024). Isolation and characterization of Bifidobacterium spp. from breast milk with different human milk oligosaccharides utilization and anti-inflammatory capacity. Food Res Int [Internet] 2024;196:115092. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0963996924011621.
Yakoob R, Pradeep BV. (2019). Bifidobacterium sp as Probiotic Agent - Roles and Applications. J Pure Appl Microbiol [Internet] 2019;13(3):1407–17. Available from: https://www.microbiologyjournal.org/bifidobacterium-sp-as-probiotic-agent-roles-and-applications/.
Sibanda T, Marole TA, Thomashoff UL, Thantsha MS, Buys EM. (2024). Bifidobacterium species viability in dairy-based probiotic foods: challenges and innovative approaches for accurate viability determination and monitoring of probiotic functionality. Front Microbiol [Internet] 2024;15. Available from: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1327010/full.
Henrick BM, Rodriguez L, Lakshmikanth T, Pou C, Henckel E, Arzoomand A, et al. (2021). Bifidobacteria-mediated immune system imprinting early in life. Cell [Internet] 2021;184(15):3884-3898.e11. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0092867421006607.
Gavzy SJ, Kensiski A, Lee ZL, Mongodin EF, Ma B, Bromberg JS. (2023). Bifidobacterium mechanisms of immune modulation and tolerance. Gut Microbes [Internet] 2023;15(2). Available from: https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2291164.
Aghamohammad S, Sepehr A, Miri ST, Najafi S, Pourshafie MR, Rohani M. (2023). Ameliorating inflammation in an in vitro model by screening the anti-inflammatory and immunomodulatory roles of putative probiotics in inflammatory bowel disease. Heliyon [Internet] 2023;9(9):e19475. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2405844023066835.
Choi YJ, Shin SH, Shin HS. (2022). Immunomodulatory Effects of Bifidobacterium spp. and Use of Bifidobacterium breve and Bifidobacterium longum on Acute Diarrhea in Children. J Microbiol Biotechnol [Internet] 2022;32(9):1186–94. Available from: http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.2206.06023.
Kullar R, Goldstein EJC, Johnson S, McFarland L V. (2023). Lactobacillus Bacteremia and Probiotics: A Review. Microorganisms [Internet] 2023;11(4):896. Available from: https://www.mdpi.com/2076-2607/11/4/896.
Dempsey E, Corr SC. (2022). Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives. Front Immunol [Internet] 2022;13. Available from: https://www.frontiersin.org/articles/10.3389/fimmu.2022.840245/full.
Wiktorczyk-Kapischke N, Grudlewska-Buda K, Budzyńska A, Chomacka-Gollus K, Gospodarek-Komkowska E, Skowron K. (2024). Antimicrobial Action of Lactobacillus spp. Isolated from Yoghurt against Escherichia coli, Salmonella Enteritidis and Listeria monocytogenes: A Pilot Study. Appl Sci [Internet] 2024;14(19):9010. Available from: https://www.mdpi.com/2076-3417/14/19/9010.
Daisley BA, Pitek AP, Chmiel JA, Gibbons S, Chernyshova AM, Al KF, et al. (2020). Lactobacillus spp. attenuate antibiotic-induced immune and microbiota dysregulation in honey bees. Commun Biol [Internet] 2020;3(1):534. Available from: https://www.nature.com/articles/s42003-020-01259-8.
Aghamohammad S, Sepehr A, Miri ST, Najafi S, Pourshafie MR, Rohani M. (2022). Anti‐inflammatory and immunomodulatory effects of Lactobacillus spp. as a preservative and therapeutic agent for IBD control. Immunity, Inflamm Dis [Internet] 2022;10(6). Available from: https://onlinelibrary.wiley.com/doi/10.1002/iid3.635.
Wang H, Luo Q, Ding X, Chen L, Zhang Z. (2022). Trimethylamine N-oxide and its precursors in relation to blood pressure: A mendelian randomization study. Front Cardiovasc Med [Internet] 2022;9. Available from: https://www.frontiersin.org/articles/10.3389/fcvm.2022.922441/full.
Tain YL, Hsu CN. (2024). Kidney Programming and Hypertension: Linking Prenatal Development to Adulthood. Int J Mol Sci [Internet] 2024;25(24):13610. Available from: https://www.mdpi.com/1422-0067/25/24/13610.
Koirala P, Garovic V, Irene Dato M, Kattah A. (2024). Role of chronic kidney disease and risk factors in preeclampsia. Pregnancy Hypertens [Internet] 2024;37:101146. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2210778924001739.
Li X, Xiao Y, Huang Y, Song L, Li M, Ren Z. (2022). Lactobacillus gasseri RW2014 Ameliorates Hyperlipidemia by Modulating Bile Acid Metabolism and Gut Microbiota Composition in Rats. Nutrients [Internet] 2022;14(23):4945. Available from: https://www.mdpi.com/2072-6643/14/23/4945.
Xu J, Moore BN, Pluznick JL. (2022). Short-Chain Fatty Acid Receptors and Blood Pressure Regulation: Council on Hypertension Mid-Career Award for Research Excellence 2021. Hypertension [Internet] 2022;79(10):2127–37. Available from: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.18558.
Miller M, Kerndt CC, Maani C V. Labetalol [Internet]. (2025). Available from: http://www.ncbi.nlm.nih.gov/pubmed/21908132.
Lin YH, Liu YH, Wu DW, Su HM, Chen SC. (2022). Dyslipidemia Increases the Risk of Incident Hypertension in a Large Taiwanese Population Follow-Up Study. Nutrients [Internet] 2022;14(16):3277. Available from: https://www.mdpi.com/2072-6643/14/16/3277.
Hosier H, Lipkind HS, Rasheed H, DeWan AT, Rogne T. (2023). Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension [Internet] 2023;80(5):1067–76. Available from: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.20426.
Zhao Y, Hong K, Zhao J, Zhang H, Zhai Q, Chen W. (2019). Lactobacillus fermentum and its potential immunomodulatory properties. J Funct Foods [Internet] 2019;56:21–32. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1756464619301161.
Cristofori F, Dargenio VN, Dargenio C, Miniello VL, Barone M, Francavilla R. (2021). Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body. Front Immunol [Internet] 2021;12. Available from: https://www.frontiersin.org/articles/10.3389/fimmu.2021.578386/full.
Lee GR. (2018). The Balance of Th17 versus Treg Cells in Autoimmunity. Int J Mol Sci [Internet] 2018;19(3):730. Available from: https://www.mdpi.com/1422-0067/19/3/730.
Dinakis E, O’Donnell JA, Marques FZ. (2024). The gut–immune axis during hypertension and cardiovascular diseases. Acta Physiol [Internet] 2024;240(8). Available from: https://onlinelibrary.wiley.com/doi/10.1111/apha.14193.
Kursun OED, Yalim G, Demirel MA, Erten F, Sahin K, Akar F. (2025). Effects of Lactobacillus plantarum on the Akt/eNOS cardiac pathway in rats with fructose-induced metabolic syndrome [pdf]. Acta Sci Pol Technol Aliment [Internet] 2025;145–56. Available from: https://www.food.actapol.net/volume24/issue1/10_1_2025.pdf.
Zhao X, Zhong X, Liu X, Wang X, Gao X. (2021). Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective From Gut Microbiota. Front Nutr [Internet] 2021;8. Available from: https://www.frontiersin.org/articles/10.3389/fnut.2021.693412/full.
Wei G, Wang D, Wang T, Wang G, Chai Y, Li Y, et al. (2025). Probiotic potential and safety properties of Limosilactobacillus fermentum A51 with high exopolysaccharide production. Front Microbiol [Internet] 2025;16. Available from: https://www.frontiersin.org/articles/10.3389/fmicb.2025.1498352/full.
Hossain TJ. (2022). Functional genomics of the lactic acid bacterium Limosilactobacillus fermentum LAB-1: metabolic, probiotic and biotechnological perspectives. Heliyon [Internet] 2022;8(11):e11412. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2405844022027001.
Pruthviraj, Naik MK, Naik RG, Nandish MS, Ekabote SD, Sreenivasa MY. (2023). Antibacterial and plant growth promoting attributes of Limosilactobacillus sp. MYSN3 isolated from noni fruit. South African J Bot [Internet] 2023;162:559–67. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0254629923005732.
Tarannum N, Ali F, Khan MS, Alhumaidan OS, Zawad ANMS, Hossain TJ. (2024). Bioactive exopolysaccharide from Limosilactobacillus fermentum LAB-1: Antioxidant, anti-inflammatory, antibacterial and antibiofilm properties. Bioact Carbohydrates Diet Fibre [Internet] 2024;31:100409. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2212619824000093.
Hao H, Nie Z, Wu Y, Liu Z, Luo F, Deng F, et al. (2024). Probiotic Characteristics and Anti-Inflammatory Effects of Limosilactobacillus fermentum 664 Isolated from Chinese Fermented Pickles. Antioxidants [Internet] 2024;13(6):703. Available from: https://www.mdpi.com/2076-3921/13/6/703.
Liu X, Zeng X, Li X, Xin S, Zhang F, Liu F, et al. (2024). Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia. J Transl Med [Internet] 2024;22(1):360. Available from: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05143-5.
de Luna Freire MO, do Nascimento LCP, de Oliveira KÁR, de Oliveira AM, Napoleão TH, Lima M dos S, et al. (2021). Effects of a Mixed Limosilactobacillus fermentum Formulation with Claimed Probiotic Properties on Cardiometabolic Variables, Biomarkers of Inflammation and Oxidative Stress in Male Rats Fed a High-Fat Diet. Foods [Internet] 2021;10(9):2202. Available from: https://www.mdpi.com/2304-8158/10/9/2202.
Zhang C, Huang H, Liu B, Tang X, Tan B, Jiang Q, et al. (2024). Optimizing Cellulase—Limosilactobacillus fermentum ZC529 Synergy Fermentation for Preserving Macadamia integrifolia Pericarp’s Potential Use as Antioxidants. Antioxidants [Internet] 2024;13(7):783. Available from: https://www.mdpi.com/2076-3921/13/7/783.
Heo S, Jung EJ, Park MK, Sung MH, Jeong DW. (2024). Evolution and Competitive Struggles of Lactiplantibacillus plantarum under Different Oxygen Contents. Int J Mol Sci [Internet] 2024;25(16):8861. Available from: https://www.mdpi.com/1422-0067/25/16/8861.
Popova-Krumova P, Danova S, Atanasova N, Yankov D. (2024). Lactic Acid Production by Lactiplantibacillus plantarum AC 11S—Kinetics and Modeling. Microorganisms [Internet] 2024;12(4):739. Available from: https://www.mdpi.com/2076-2607/12/4/739.
Zhang Z, Niu H, Qu Q, Guo D, Wan X, Yang Q, et al. (2025). Advancements in Lactiplantibacillus plantarum : probiotic characteristics, gene editing technologies and applications. Crit Rev Food Sci Nutr [Internet] 2025;1–22. Available from: https://www.tandfonline.com/doi/full/10.1080/10408398.2024.2448562.
Ma W, Sun H, Lian L, Guo L, Wang Y, Huang L. (2025). Immunomodulatory effects of Lactiplantibacillus plantarum CCFM8661 + stachyose on cyclophosphamide-induced immunosuppression mice. Front Immunol [Internet] 2025;16. Available from: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513531/full.
Tobias J, Heinl S, Dendinovic K, Ramić A, Schmid A, Daniel C, et al. (2025). The benefits of Lactiplantibacillus plantarum: From immunomodulator to vaccine vector. Immunol Lett [Internet] 2025;272:106971. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0165247825000033
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