A Narrative Review of Aromatherapy for Pain Management in Diabetic Peripheral Neuropathy
DOI:
https://doi.org/10.37287/ijghr.v9i1.2882Keywords:
aromatherapy, diabetic neuropathy, essential oil, neuropathic pain, quality of lifeAbstract
Painful diabetic peripheral neuropathy can disturb sleep, limit daily activities and reduce quality of life. Aromatherapy has attracted interest as an adjunct to usual care, although its specific benefits remain uncertain. To critically examine evidence on aromatherapy for pain and quality of life in diabetic peripheral neuropathy. PubMed, Europe PMC and OpenAlex searches on 10 until 16 October 2026 retrieved 354 raw records. Twenty-six sources published in 2008–2026 were cited, including 11 clinical reports. Reports were appraised for design, intervention, comparator, outcomes and reporting consistency, then synthesised thematically. Seven massage studies generally reported short-term pain improvement. Usual-care comparisons could not separate essential-oil effects from massage and attention. Three topical trials produced mixed findings; one study contributed a small diabetic subgroup. Quality-of-life findings varied. Limited blinding, inconsistent reporting and short follow-up restricted interpretation. Aromatherapy massage may provide adjunctive short-term pain relief. Evidence does not establish benefits attributable specifically to essential oils, a standard regimen, lasting improvement or nerve regeneration.
References
Abdel Hamid Hawash, M., Gamal Ramadan Asal, M., & Ramadan Shaheen Ibrahim, S. (2023). Effect of aromatherapy massage with chamomile oil versus lavender oil on neuropathic pain and quality of life in diabetic patients: Randomized controlled clinical trial. Egyptian Journal of Health Care, 14(2), 724–737. https://doi.org/10.21608/ejhc.2023.302778
American Diabetes Association Professional Practice Committee for Diabetes. (2026). 12. Retinopathy, neuropathy, and foot care: Standards of Care in Diabetes 2026. Diabetes Care, 49(Suppl. 1), S261–S276. https://doi.org/10.2337/dc26-S012
Amiri, M., Imani, M. H., Imani, A. H., Bazrafshan, H., Bazrafshan, M., Vardanjani, H. M., & Zohalinezhad, M. E. (2025). Topical chamomile oil as a novel therapeutic intervention for diabetic neuropathy: A randomized double-blind controlled clinical trial. EXPLORE, 21(4), 103189. https://doi.org/10.1016/j.explore.2025.103189
Aqila, H., Masykur, U. J., Janet, K. A., Sulistomo, H. W., & Kurniawan, S. N. (2026). Comparative effectiveness of non-pharmacological interventions for diabetic neuropathic pain: A network meta-analysis of pain intensity and neuropathic symptom outcomes. MNJ (Malang Neurology Journal), 12(2), 149–163. https://doi.org/10.21776/ub.mnj.2026.012.02.08
Aykemat, Y., Doğru, B. V., & Serin, E. K. (2026). The effect of aromatherapy on quality of life in patients with type 2 diabetes mellitus: A systematic review. Journal of Diabetes & Metabolic Disorders, 25(2), 219. https://doi.org/10.1007/s40200-026-02033-z
Baethge, C., Goldbeck-Wood, S., & Mertens, S. (2019). SANRA: A scale for the quality assessment of narrative review articles. Research Integrity and Peer Review, 4, 5. https://doi.org/10.1186/s41073-019-0064-8
Beshara, R. A., Abd El-Hay, S. A., Frag, W. F., & Abdallah, A. K. (2026). Effect of aromatherapy massage on neuropathic pain and quality of life of diabetic patients. Tanta Scientific Nursing Journal, 40(1, Suppl. 2), 70–90. https://doi.org/10.21608/tsnj.2026.497511
Boyd, A., Bleakley, C., Hurley, D. A., Gill, C., Hannon-Fletcher, M., Bell, P., & McDonough, S. (2019). Herbal medicinal products or preparations for neuropathic pain. Cochrane Database of Systematic Reviews, 2019(4), CD010528. https://doi.org/10.1002/14651858.CD010528.pub4
Cho, M.-K., & Kim, M. Y. (2024). The effect of aromatherapy on pain in individuals with diabetes: A systematic review and meta-analysis. Journal of Korean Biological Nursing Science, 26(2), 71–82. https://doi.org/10.7586/jkbns.24.012
Dworkin, R. H., Turk, D. C., Wyrwich, K. W., Beaton, D., Cleeland, C. S., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Kerns, R. D., Ader, D. N., Brandenburg, N., Burke, L. B., Cella, D., Chandler, J., Cowan, P., Dimitrova, R., Dionne, R., Hertz, S., Jadad, A. R., ... Zavisic, S. (2008). Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. The Journal of Pain, 9(2), 105–121. https://doi.org/10.1016/j.jpain.2007.09.005
Elafros, M. A., Andersen, H., Bennett, D. L., Savelieff, M. G., Viswanathan, V., Callaghan, B. C., & Feldman, E. L. (2022). Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. The Lancet Neurology, 21(10), 922–936. https://doi.org/10.1016/S1474-4422(22)00188-0
Gok Metin, Z., Arikan Donmez, A., Izgu, N., Ozdemir, L., & Arslan, I. E. (2017). Aromatherapy massage for neuropathic pain and quality of life in diabetic patients. Journal of Nursing Scholarship, 49(4), 379–388. https://doi.org/10.1111/jnu.12300
Hashimoto, M., Takahashi, K., & Ohta, T. (2023). Inhibitory effects of linalool, an essential oil component of lavender, on nociceptive TRPA1 and voltage-gated Ca2+ channels in mouse sensory neurons. Biochemistry and Biophysics Reports, 34, 101468. https://doi.org/10.1016/j.bbrep.2023.101468
Hoffmann, T. C., Glasziou, P. P., Boutron, I., Milne, R., Perera, R., Moher, D., Altman, D. G., Barbour, V., Macdonald, H., Johnston, M., Lamb, S. E., Dixon-Woods, M., McCulloch, P., Wyatt, J. C., Chan, A.-W., & Michie, S. (2014). Better reporting of interventions: Template for intervention description and replication (TIDieR) checklist and guide. BMJ, 348, g1687. https://doi.org/10.1136/bmj.g1687
Kholifah, N., Purnama, A., & Afrina, R. (2025). The effect of aromatherapy massage with lavender oil on pain levels and quality of life in diabetic neuropathy patients. Open Access Health Scientific Journal, 6(2), 186–192. https://doi.org/10.55700/oahsj.v6i2.74
Li, L. (2010). The effect of Neuragen PN on neuropathic pain: A randomized, double blind, placebo controlled clinical trial. BMC Complementary and Alternative Medicine, 10(1), 22. https://doi.org/10.1186/1472-6882-10-22
Meutia, R. T. M., Marlindawani, J., & Ritarwan, K. (2023). Intervensi massage aromaterapi (lavender) terhadap penurunan intensitas nyeri penderita neuropathy diabetic [Lavender aromatherapy massage to reduce pain intensity in diabetic neuropathy]. Journal of Telenursing (JOTING), 5(1), 279–289. https://doi.org/10.31539/joting.v5i1.4232
Mohammed, A. S., Hassanein, S. M., Soliman, F. M., & Elsheimy, H. A. (2019). Effect of aromatherapy massage on neuropathic pain among patients with type II diabetes mellitus. International Journal of Novel Research in Healthcare and Nursing, 6(3), 1077–1086. https://www.noveltyjournals.com/upload/paper/Effect%20of%20Aromatherapy-2127.pdf
Motilal, S., & Maharaj, R. G. (2013). Nutmeg extracts for painful diabetic neuropathy: A randomized, double-blind, controlled study. The Journal of Alternative and Complementary Medicine, 19(4), 347–352. https://doi.org/10.1089/acm.2012.0016
Musharraf, M. U., Ahmad, Z., & Yaqub, Z. (2017). Comparison of topical capsaicin and topical turpentine oil for treatment of painful diabetic neuropathy. Journal of Ayub Medical College Abbottabad, 29(3), 384–387. https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/2107
Nasiri Lari, Z., Hajimonfarednejad, M., Riasatian, M., Abolhassanzadeh, Z., Iraji, A., Vojoud, M., Heydari, M., & Shams, M. (2020). Efficacy of inhaled Lavandula angustifolia Mill. essential oil on sleep quality, quality of life and metabolic control in patients with diabetes mellitus type II and insomnia. Journal of Ethnopharmacology, 251, 112560. https://doi.org/10.1016/j.jep.2020.112560
Posadzki, P., Alotaibi, A., & Ernst, E. (2012). Adverse effects of aromatherapy: A systematic review of case reports and case series. International Journal of Risk & Safety in Medicine, 24(3), 147–161. https://doi.org/10.3233/JRS-2012-0568
Price, R., Smith, D., Franklin, G., Gronseth, G., Pignone, M., David, W. S., Armon, C., Perkins, B. A., Bril, V., Rae-Grant, A., Halperin, J., Licking, N., O'Brien, M. D., Wessels, S. R., MacGregor, L. C., Fink, K., Harkless, L. B., Colbert, L., & Callaghan, B. C. (2022). Oral and topical treatment of painful diabetic polyneuropathy: Practice guideline update summary: Report of the AAN Guideline Subcommittee. Neurology, 98(1), 31–43. https://doi.org/10.1212/WNL.0000000000013038
Ridouh, I., & Hackshaw, K. V. (2022). Essential oils and neuropathic pain. Plants, 11(14), 1797. https://doi.org/10.3390/plants11141797
Rivaz, M., Rahpeima, M., Khademian, Z., & Dabbaghmanesh, M. H. (2021). The effects of aromatherapy massage with lavender essential oil on neuropathic pain and quality of life in diabetic patients: A randomized clinical trial. Complementary Therapies in Clinical Practice, 44, 101430. https://doi.org/10.1016/j.ctcp.2021.101430
Sanna, M. D., Les, F., Lopez, V., & Galeotti, N. (2019). Lavender (Lavandula angustifolia Mill.) essential oil alleviates neuropathic pain in mice with spared nerve injury. Frontiers in Pharmacology, 10, 472. https://doi.org/10.3389/fphar.2019.00472
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