Clinical and Hematological Correlates of TUBEX-TF Anti-O9 IgM Reactivity in Children with Typhoid Fever
DOI:
https://doi.org/10.37287/ijghr.v8i6.2857Keywords:
children, hematological parameters, lymphocytes, TUBEX-TF, typhoid feverAbstract
Typhoid fever is a major pediatric health burden, yet the biological significance of varying semiquantitative TUBEX-TF reactivity levels remains unclear. To investigate the relationship between clinical manifestations, routine hematological parameters, and TUBEX-TF reactivity in pediatric typhoid fever. This cross-sectional study utilized medical records of children aged 0–18 years diagnosed with typhoid fever at Haji Adam Malik General Hospital, Medan, from 2023 to 2024. This study used purposive sampling, and included 142 samples. Patients were then stratified into TUBEX-TF score 4 and 6 groups. Data were analyzed using Chi-square, Fisher's exact, and Mann-Whitney U tests. The study included 142 children (mean age 10.8 years; 55.6% male), with 84 (59.2%) having a score of 6. No significant differences were found between the score groups regarding clinical manifestations, hemoglobin, leukocyte or platelet counts, and most leukocyte differentials. However, lymphocyte percentage was significantly higher in the score 6 group compared to the score 4 group (26.76 ± 17.91% vs. 20.57 ± 16.05%; p=0.031). Higher TUBEX-TF reactivity did not correspond with differences in clinical manifestations or most routine blood parameters.
References
Agrawal, A., Sharma, S., Janjua, D., Jadon, G., Chanchlani, R., & Dsouza, V. (2025). Impact of nutritional status on the mortality and clinical outcomes of children admitted to the pediatric intensive care unit: A systematic review and meta-analysis. Clinical Nutrition, 51, 28–39. https://doi.org/10.1016/j.clnu.2025.06.002
Enkelmann, J., Simon, S., Trost, E., Stark, K., & Frank, C. (2025). Epidemiological characteristics and trends of notified enteric fevers in Germany, 2001 to 2023. Eurosurveillance, 30(14). https://doi.org/10.2807/1560-7917.ES.2025.30.14.2400314
Etouke, T. A. N., Ful Kuh, G., Nzesseu, V. L., Gomseu, B. E. D., Tamokou, J.-D.-D., & Dzoyem, J. P. (2023). Association of Biochemical and Hematological Parameters With Enteric Fever Infection at the Dschang Regional Annex Hospital, Cameroon: A Cross-Sectional Study. Cureus. https://doi.org/10.7759/cureus.40498
Hartanto, D. (2021). Diagnosis dan Tatalaksana Demam Tifoid pada Dewasa. Cermin Dunia Kedokteran, 48(1), 5. https://doi.org/10.55175/cdk.v48i1.1255
Liu, W., Liao, K., Wu, J., Liu, S., Zheng, X., Wen, W., Fu, L., Fan, X., Yang, X., Hu, X., Jiang, Y., Wu, K., Guo, Z., Li, Y., Liu, W., Cai, M., Guo, Z., Guo, X., Lu, J., … Chen, D. (2024). Blood culture quality and turnaround time of clinical microbiology laboratories in Chinese Teaching Hospitals: A multicenter study. Journal of Clinical Laboratory Analysis, 38(1–2), e25008. https://doi.org/10.1002/jcla.25008
Murni, I. K., Duke, T., Kinney, S., Daley, A. J., Wirawan, M. T., & Soenarto, Y. (2022). Risk factors for healthcare-associated infection among children in a low-and middle-income country. BMC Infectious Diseases, 22(1), 406. https://doi.org/10.1186/s12879-022-07387-2
Nugraheni, E., Syahrurachman, A., Dewi, B., Nainggolan, L., Arodes, E. S., & Mulyadi, M. (2022). Hematology Parameter Based on Tubex TF® Color Scale Result in Typhoid Fever Patients. Open Access Macedonian Journal of Medical Sciences, 10(A), 1028–1032. https://doi.org/10.3889/oamjms.2022.9690
Nurmawati, S., Alam, A., Djauhari, H., Merati, T. P., Sudarmono, P., Setiawaty, V., Arlinda, D., Sugiyono, R. I., Arief, M., Hadi, U., Aman, A. T., Lokida, D., Gasem, M. H., Tjitra, E., Liang, C. J., Neal, A., Kosasih, H., Karyana, M., Lau, C.-Y., & Alisjahbana, B. (2024). Clinical characteristics of enteric fever and performance of TUBEX TF IgM test in Indonesian hospitals. PLoS Neglected Tropical Diseases, 18(7), e0011848. https://doi.org/10.1371/journal.pntd.0011848
Ringoringo, H. P., Mentari, J. R. S., Hartoyo, E., & Lao, R. (2022). Hematological profile of children under five years with typhoid fever at Idaman Banjarbaru Hospital, Indonesia. Bali Medical Journal, 11(2), 775–778. https://doi.org/10.15562/bmj.v11i2.2669
Shafqat, Z., Kanwal, S., Yousaf, A., Shafqat, A., Kamal, Z., Zahid, M. I., & Shabir, S. (2025). Clinical Spectrum and Outcomes of Typhoid Fever: A Retrospective Study. Cureus. https://doi.org/10.7759/cureus.94621
Shao, H., Zhang, X., Li, Y., Gao, Y., Wang, Y., Shao, X., & Dai, L. (2024). Epidemiology and drug resistance analysis of bloodstream infections in an intensive care unit from a children’s medical center in Eastern China for six consecutive years. International Microbiology, 27(5), 1345–1355. https://doi.org/10.1007/s10123-024-00481-2
Tahir, N., Khattak, S., Jamal, N., Shaikh, G., Ahmed, R., & Ahmed, W. (2024). Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital. Journal of Liaquat University of Medical & Health Sciences, 23(01), 53–57. https://doi.org/10.22442/jlumhs.2024.01082
Tipah, T. D., Nnadi, N. E., & Slavcev, R. A. (2026). Phage-Based Vaccine Platforms for Typhoid Fever: A Transformative Approach to Global Health and Antimicrobial Resistance. Vaccines, 14(10), 869. https://doi.org/10.3390/vaccines14100869
Webster, J. L., Stauffer, W. M., Mitchell, T., Lee, D., O’Connell, E. M., Weinberg, M., Nutman, T. B., Sakulrak, P., Tongsukh, D., & Phares, C. R. (2022). Cross-Sectional Assessment of the Association of Eosinophilia with Intestinal Parasitic Infection in U.S.-Bound Refugees in Thailand: Prevalent, Age Dependent, but of Limited Clinical Utility. The American Journal of Tropical Medicine and Hygiene, 106(5), 1552–1559. https://doi.org/10.4269/ajtmh.21-0853
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