Efficacy of Combined Channa Striata and Curcumin Supplementation to Enhance Quality of Life among NSCLC Patients Undergoing Chemotherapy: A Randomized, Double-Blind, Controlled Trial
DOI:
https://doi.org/10.37287/ijghr.v8i5.2184Keywords:
channa striata, curcumin, non-small cell lung cancer, quality of lifeAbstract
Chemotherapy remains a cornerstone treatment for non-small cell lung cancer (NSCLC), but treatment-related toxicities frequently contribute to nutritional deterioration and impaired quality of life (QoL). Nutritional supplementation may help support patients during treatment. This study evaluated the efficacy of combined Channa striata extract and Curcumin supplementation in improving health-related quality of life among patients with NSCLC undergoing chemotherapy. This study aimed to assess the effects of combined Channa striata extract and Curcumin supplementation on changes in health-related quality of life among patients with non–small cell lung cancer receiving chemotherapy. A randomized, double-blind, placebo-controlled trial was conducted among newly diagnosed NSCLC patients receiving chemotherapy. Participants were randomly assigned to receive either a combination of Channa striata extract and Curcumin (Striatamin®, PT Mega Medica) or placebo during two chemotherapy cycles. Quality of life was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) at baseline and after treatment. Thirty-two patients were enrolled, with 16 patients in each group. On the EORTC QLQ-C30 functional scale, social functioning improved significantly in the intervention group compared with the control group after the second chemotherapy cycle (45.06 ± 25.65 vs. 33.33, p = 0.049). The intervention group also demonstrated a significantly greater improvement in global health status than the control group (12.49 ± 12.57 vs. 8.27, p = 0.041). Although numerical improvements were observed in several symptom domains, no significant differences were found between groups on the symptom scale (p > 0.05). Administration of a combination of Channa striata and Curcumin up to the second chemotherapy cycle was shown to improve quality of life, particularly in the social functioning domain, and to significantly enhance overall health in patients with NSCLC.
References
Akter, K., Rahman, M. M., & Colleagues. (2025). Revisiting curcumin in cancer therapy: Recent insights into molecular mechanisms and clinical applications. Biomedicines.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12468695/
Bray Bsc, F., Laversanne, | Mathieu, Hyuna, |, Phd, S., Ferlay, J., Siegel Mph, R. L., Soerjomataram, I., Ahmedin, |, & Dvm, J. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 74(3), 229–263. https://doi.org/10.3322/CAAC.21834
Cardellini, S., Deantoni, C. L., Paccagnella, M., Casirati, A., Pontara, A., Marinosci, A., Tresoldi, M., Giordano, L., Chiara, A., Dell’Oca, I., Di Muzio, N. G., Caccialanza, R., & Mirabile, A. (2024). The impact of nutritional intervention on quality of life and outcomes in patients with head and neck cancers undergoing chemoradiation. Frontiers in Oncology, 14, Article 1475930. https://doi.org/10.3389/fonc.2024.1475930
Cocks, K., Wells, J. R., Johnson, C., Schmidt, H., Koller, M., Oerlemans, S., Velikova, G., Pinto, M., Tomaszewski, K. A., Aaronson, N. K., Exall, E., Finbow, C., Fitzsimmons, D., Grant, L., Groenvold, M., Tolley, C., Wheelwright, S., & Bottomley, A. (2023). Content validity of the EORTC quality of life questionnaire QLQ-C30 for use in cancer. European Journal of Cancer, 178, 128–138. https://doi.org/10.1016/j.ejca.2022.10.026
Ding, Y., Wang, X., Zhang, F., Yan, H., Liu, Y., & Zhang, L. (2024). The relationship between perceived social support, coping style, and the quality of life and psychological state of lung cancer patients. BMC Psychology, 12(1). https://doi.org/10.1186/s40359-024-01927-y
Fayers, P. M. ., Aaronson, Neil., Bjordal, Kristin., Groenvold, Mogens., Curran, Desmond., & Bottomley, Andrew. (2001). EORTC QLQ-C30 scoring manual : this manual is intended to assist users with scoring procedures for the QLQ-C30 version 3 and earlier, and the QLQ supplementary modules. EORTC.
Guo, L., Zhu, C., Cai, L., Zhang, X., Fang, Y., Chen, H., & Yang, H. (2024). Global burden of lung cancer in 2022 and projected burden in 2050. Chinese Medical Journal, 137(21), 2577–2582. https://doi.org/10.1097/CM9.0000000000003268
Hechtner, M., Eichler, M., Wehler, B., Buhl, R., Sebastian, M., Stratmann, J., Schmidberger, H., Gohrbandt, B., Peuser, J., Kortsik, C., Nestle, U., Wiesemann, S., Wirtz, H., Wehler, T., Bals, R., Blettner, M., & Singer, S. (2019). Quality of Life in NSCLC Survivors — A Multicenter Cross-Sectional Study. Journal of Thoracic Oncology, 14(3), 420–435. https://doi.org/10.1016/j.jtho.2018.11.019
Jianrong Zhang, M. J. Ij. J. O. N. K. R. J. B. F. F. P. D. X. W. J. D. E. (2022). Time to diagnosis and treatment of lung cancer: A systematic overview of risk factors, interventions and impact on patient outcomes. Elsevier.
Krzywon, A., Kotylak, A., Cortez, A. J., Mrochem-Kwarciak, J., Składowski, K., & Rutkowski, T. (2023).
Influence of nutritional counseling on treatment results in patients with head and neck cancers. Nutrition, 116, 112187. https://doi.org/10.1016/j.nut.2023.112187
Miramontes-González, J. P., García-Luna, P. P., & Colleagues. (2025). Nutrition in lung cancer treatment: The forgotten pillar of care? Chinese Clinical Oncology. https://cco.amegroups.org/article/view/142129/html
Musliha, A., Dermawan, D., Rahayu, P., & Tjandrawinata, R. R. (2024). Unraveling modulation effects on albumin synthesis and inflammation by Striatin, a bioactive protein fraction isolated from Channa striata: In silico proteomics and in vitro approaches. Heliyon, 10(19). https://doi.org/10.1016/j.heliyon.2024.e38386
Ninfa, A., Jansen, F., Delle Fave, A., Lissenberg-Witte, B. I., Pizzorni, N., Baatenburg de Jong, R. J., et al. (2023). The change in social eating over time in people with head and neck cancer treated with primary (chemo)radiotherapy: The role of swallowing, oral function, and nutritional status. Cancers, 15(5), 1603.
https://doi.org/10.3390/cancers15051603
Polański, J., Jankowska-Polańska, B., & Mazur, G. (2021). Relationship between nutritional status and quality of life in patients with lung cancer. Cancer Management and Research, 13, 1407–1416. https://doi.org/10.2147/CMAR.S287551
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/CAAC.21660
Tian, Y., Zhao, W. Y., Liu, Y. R., Song, W. W., Lin, Q. X., Gong, Y. N., Deng, Y. T., Gu, D. N., & Tian, L. (2024). Machine learning reveals CAT gene as a novel potential diagnostic and prognostic biomarker in non-small cell lung cancer. Discover Oncology, 15(1). https://doi.org/10.1007/s12672-024-01670-1
Wan Nur Baitty Wan Mohd Tajuddin, Nordin H. Lajis, Faridah Abas, Iekhsan Othman, & ORCID andRakesh Naidu. (2019). Mechanistic Understanding of Curcumin’s Therapeutic Effects in Lung Cancer. Https://Doi.Org/10.3390/Nu11122989. https://doi.org/10.3390/nu11122989
Wu, Q., Ou, H., Shang, Y., Zhang, X., Wu, J., & Fan, F. (2021). Nanoscale formulations: Incorporating curcumin into combination strategies for the treatment of lung cancer. In Drug Design, Development and Therapy (Vol. 15, pp. 2695–2709). Dove Medical Press Ltd. https://doi.org/10.2147/DDDT.S311107
Yan, N., Guo, S., Zhang, H., Zhang, Z., Shen, S., & Li, X. (2022). BRAF-Mutated Non-Small Cell Lung Cancer: Current Treatment Status and Future Perspective. In Frontiers in Oncology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fonc.2022.863043
Zhang, F., Zhong, S., Wei, Q., Zhang, H., Hu, H., Zeng, B., & Zheng, X. (2024). Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy(HAIC) Combined with PD-1 Inhibitors for Advanced Hepatocellular Carcinoma with Macrovascular Invasion: A Multicenter Propensity Score Matching Analysis. Journal of Hepatocellular Carcinoma, 11, 1961–1978. https://doi.org/10.2147/JHC.S483824
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Indonesian Journal of Global Health Research
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
