AI-Driven Wearable HRV Monitoring for Early Detection of Nurse Fatigue and Its Impact on Clinical Performance and Patient Safety: A Systematic Literature Review
DOI:
https://doi.org/10.37287/ijghr.v8i1.1160Keywords:
artificial intelligence, biofeedback, heart rate variability, nurse fatigue, wearable technologyAbstract
Nurse fatigue is a major occupational health concern that negatively affects clinical performance, recovery, and patient safety. Prolonged working hours, night shifts, and job-related stress disrupt autonomic balance and increase the likelihood of clinical errors. Heart Rate Variability (HRV) has been widely recognised as a sensitive physiological biomarker of fatigue and occupational stress. Integrating Artificial Intelligence (AI) with HRV-enabled wearable technology offers a promising approach for real-time and objective fatigue monitoring in nursing populations. This systematic literature review aimed to synthesise evidence on AI-enhanced HRV wearable technology for early detection and management of nurse fatigue. The review followed PRISMA guidelines and was registered in PROSPERO (CRD420251251457). Searches were conducted across six electronic databases (Scopus, ProQuest, ScienceDirect, SAGE, Wiley, and SpringerLink) using predefined Boolean keywords, including “wearable device”, “wearable technology”, “smartwatch”, “heart rate variability”, “artificial intelligence”, “machine learning”, “nurse*”, “nursing practice”, “fatigue”, and “clinical decision support”*. Articles published in English between 2015 and 2025 were included. From 1,689 records identified, 11 studies met the inclusion criteria after screening and methodological quality appraisal using Joanna Briggs Institute tools. AI-integrated wearable systems demonstrated high diagnostic performance, with fatigue detection accuracy around 80% for machine learning models and exceeding 99% for multimodal biosensing systems. Physiological biomarkers—including HRV, cortisol, electrodermal activity, and skin temperature—consistently reflected objective fatigue, particularly during extended working hours. Intervention studies showed that AI-supported HRV biofeedback and cognitive behavioural approaches improved autonomic regulation and nurse wellbeing. AI-enabled HRV wearable technology represents a feasible and promising strategy for early fatigue detection and wellbeing optimisation among nurses, with potential benefits for clinical performance and patient safety. However, practical implementation and long-term integration into healthcare systems remain key considerations for future research.
References
Ahmadi, N., Sasangohar, F., Nisar, T., Danesh, V., Sultana, I., & Bosetti, R. (2021). Quantifying Occupational Stress in Intensive Care Unit Nurses: An Applied Naturalistic Study of Correlations Among Stress, Heart Rate, Electrodermal Activity, and Skin Temperature.
Hafiz, W. S., Puspasari, M. A., Fitriani, D. Y., Hanowski, R. J., Syaifullah, D. H., & Arista, S. A. (2025). Developing a Fatigue Detection Model for Hospital Nurses Using HRV Measures and Machine Learning. Safety, 11(2). https://doi.org/10.3390/safety11020048
Jelmini, J. D., Ross, J., Whitehurst, L. N., & Heebner, N. R. (2023). The effect of extended shift work on autonomic function in occupational settings: A systematic review and meta-analysis. In Journal of Occupational Health (Vol. 65, Issue 1). Oxford University Press. https://doi.org/10.1002/1348-9585.12409
Kim, J. E., Kim, N. H., Choi, S. K., Lee, J. Y., Lee, K., & Han, J. S. (2025). Machine learning-based fatigue classification using heart rate variability and cortisol: A multimodal approach to wearable health monitoring. Digital Health, 11. https://doi.org/10.1177/20552076251395570
Leso, V., Fontana, L., Caturano, A., Vetrani, I., Fedele, M., & Iavicoli, I. (2021). Impact of shift work and long working hours on worker cognitive functions: Current evidence and future research needs. In International Journal of Environmental Research and Public Health (Vol. 18, Issue 12). MDPI. https://doi.org/10.3390/ijerph18126540
Li, K., Cardoso, C., Moctezuma-Ramirez, A., Elgalad, A., & Perin, E. (2023). Heart Rate Variability Measurement through a Smart Wearable Device: Another Breakthrough for Personal Health Monitoring? In International Journal of Environmental Research and Public Health (Vol. 20, Issue 24). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/ijerph20247146
Li, X., Zhu, W., Sui, X., Zhang, A., Chi, L., & Lv, L. (2022). Assessing Workplace Stress Among Nurses Using Heart Rate Variability Analysis With Wearable ECG Device–A Pilot Study. Frontiers in Public Health, 9. https://doi.org/10.3389/fpubh.2021.810577
Liu, S. S. H., Ma, C. J., Chou, F. Y., Cheng, M. Y. C., Wang, C. H., Tsai, C. L., Duh, W. J., Huang, C. H., Lai, F., & Lu, T. C. (2023). Applying a Smartwatch to Predict Work-related Fatigue for Emergency Healthcare Professionals: Machine Learning Method. Western Journal of Emergency Medicine, 24(4), 693–702. https://doi.org/10.5811/westjem.58139
Macedo, A. B. T., Vega, E. A. U., Antoniolli, L., Pinheiro, J. M. G., Tavares, J. P., & Souza, S. B. C. de. (2023). Effect of cardiovascular biofeedback on nursing staff stress: a randomized controlled clinical trial. Revista Brasileira de Enfermagem, 76(6). https://doi.org/10.1590/0034-7167-2023-0069
Mensinger, J. L., Weissinger, G. M., Cantrell, M. A., Baskin, R., & George, C. (2024). A Pilot Feasibility Evaluation of a Heart Rate Variability Biofeedback App to Improve Self-Care in COVID-19 Healthcare Workers. Applied Psychophysiology Biofeedback, 49(2), 241–259. https://doi.org/10.1007/s10484-024-09621-w
Park, J., Zhong, X., Dong, Y., Barwise, A., & Pickering, B. W. (2022). Investigating the cognitive capacity constraints of an ICU care team using a systems engineering approach. BMC Anesthesiology, 22(1). https://doi.org/10.1186/s12871-021-01548-7
Penfold, S. M., Cunningham, J., Whelan, P., McCabe, M. G., & Ainsworth, J. (2025). Decreased Heart Rate Variability Is Associated with Increased Fatigue Across Different Medical Populations: A Systematic Review. In Pathophysiology (Vol. 32, Issue 3). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/pathophysiology32030046
Raj, A., & Sapra, P. (2026). AI in Healthcare Sector: A Systematic Review on the Detection of (HRV) Through Wearable Watches. In A. Kr. Shukla, P. Singh, & P. Sharma (Eds.), Smart Generation Computing and Communication Networks (pp. 219–226). Springer Nature Switzerland.
Review, M., & Raines, E. (2024). Advancements in Wearable Biosensors for Continuous Health Monitoring. https://doi.org/10.37421/2155-6210.2024.15.434
Sharma, A., Sharma, A., & Sharma, P. (n.d.). AI-ENABLED WEARABLES IN HEALTHCARE: A COMPREHENSIVE REVIEW. International Journal of Medicine and Public Health, 15. https://doi.org/10.70034/ijmedph.2025.4.94
Shen, Y., Fang, Z., Zhang, T., Yu, F., Xu, Y., & Yang, L. (2025). Heart rate variability with circadian rhythm removed achieved high accuracy for stress assessment across all times throughout the day. Frontiers in Physiology, 16. https://doi.org/10.3389/fphys.2025.1535331
Wang, J., Wang, X., Qiao, S., La, H., Yu, Y., & An, X. (2025). Investigation of fatigue mechanisms and detection methods for anesthesiologists based on multimodal physiological signals. Brain Research Bulletin, 232. https://doi.org/10.1016/j.brainresbull.2025.111597
Zeng, Z., Zhou, S., & Liu, M. (2024). Research progress on assessment tools related to occupational fatigue in nurses: a traditional review. In Frontiers in Public Health (Vol. 12). Frontiers Media SA. https://doi.org/10.3389/fpubh.2024.1508071
Zhan, T., Zhang, Z., Shi, Z., Xie, H., Zha, D., & Wei, X. (2025). Factors influencing heart rate variability in nurses following night shifts: a prospective observational clinical study. BMC Nursing, 24(1), 1318. https://doi.org/10.1186/s12912-025-03975-0.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Indonesian Journal of Global Health Research

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.







